Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 42, 2013
Previous Article Next Article

Confinement induced stochastic sensing of charged coronene and perylene aggregates in α-hemolysin nanochannels

Author affiliations

Abstract

Biological nanopores provide optimum dimensions and an optimal environment to study early aggregation kinetics of charged polyaromatic molecules in the nano-confined regime. It is expected that probing early stages of nucleation will enable us to design a strategy for supramolecular assembly and biocrystallization processes. Specifically, we have studied translocation dynamics of coronene and perylene based salts, through the α-hemolysin (α-HL) protein nanopore. The characteristic blocking events in the time-series signal are a function of concentration and bias voltage. We argue that different blocking events arise due to different aggregation processes as captured by all atomistic molecular dynamics (MD) simulations. These confinement induced aggregations of polyaromatic chromophores during the different stages of translocation are correlated with the spatial symmetry and charge distribution of the molecules.

Graphical abstract: Confinement induced stochastic sensing of charged coronene and perylene aggregates in α-hemolysin nanochannels

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 10 May 2013, accepted on 04 Sep 2013 and first published on 05 Sep 2013


Article type: Paper
DOI: 10.1039/C3SM51313K
Citation: Soft Matter, 2013,9, 10196-10202
  •   Request permissions

    Confinement induced stochastic sensing of charged coronene and perylene aggregates in α-hemolysin nanochannels

    R. Shivanna, D. Pramanik, H. Kumar, K. V. Rao, S. J. George, P. K. Maiti and K. S. Narayan, Soft Matter, 2013, 9, 10196
    DOI: 10.1039/C3SM51313K

Search articles by author