Issue 12, 2013

Glycopolypeptide conformations in bioactive block copolymer assemblies influence their nanoscale morphology

Abstract

We describe the preparation and assembly of glycosylated amphiphilic diblock copolypeptides, where the hydrophilic glycosylated segments adopt either α-helical or disordered conformations. In this study, glycosylated amphiphilic diblock copolypeptides were prepared using poly(L-leucine), poly(L), as the hydrophobic segment, and poly(α-D-galactopyranosyl-L-lysine), poly(α-gal-K), or poly(α-D-galactopyranosyl-L-cysteine sulfone), poly(α-gal-CO2), as the hydrophilic segment. The poly(α-gal-K) and poly(α-gal-CO2) segments are known to be fully α-helical (>90% at 20 °C) and fully disordered in water, respectively. We found that block copolypeptides containing galactosylated hydrophilic segments of either α-helical or disordered conformation give different assembly morphologies, where the disordered glycopolypeptide segments favor vesicle formation and also present sugar residues that can bind to biological targets.

Graphical abstract: Glycopolypeptide conformations in bioactive block copolymer assemblies influence their nanoscale morphology

Supplementary files

Article information

Article type
Paper
Submitted
06 Nov 2012
Accepted
22 Jan 2013
First published
11 Feb 2013
This article is Open Access
Creative Commons BY license

Soft Matter, 2013,9, 3389-3395

Glycopolypeptide conformations in bioactive block copolymer assemblies influence their nanoscale morphology

J. R. Kramer, A. R. Rodriguez, U. Choe, D. T. Kamei and T. J. Deming, Soft Matter, 2013, 9, 3389 DOI: 10.1039/C3SM27559K

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