Jump to main content
Jump to site search

Issue 10, 2013
Previous Article Next Article

Probing interactions of the HIV protein GP120 with lipids and CD4 receptors

Author affiliations

Abstract

HIV viral protein interactions with cellular receptors are vital to the infection process. It is in this context that the HIV GP120 viral envelope protein interactions with lipid bilayers and CD4 receptors have been studied. It was demonstrated that the GP120 protein “sinks” into the lipid bilayer over time, a significant ability when considering its biological role. GP120 can also assemble into larger structures on lipid bilayers and forms unusual micron scale aggregates when preformed complexes are deposited on mica. It is possible to distinguish individual GP120/CD4 complexes when the receptor is reconstituted into the lipid bilayer with the force required to unfold the complex greater than the force required to unfold either of the individual components.

Graphical abstract: Probing interactions of the HIV protein GP120 with lipids and CD4 receptors

Back to tab navigation

Supplementary files

Publication details

The article was received on 16 Oct 2012, accepted on 18 Dec 2012 and first published on 04 Jan 2013


Article type: Paper
DOI: 10.1039/C2SM27387J
Citation: Soft Matter, 2013,9, 2803-2809
  •   Request permissions

    Probing interactions of the HIV protein GP120 with lipids and CD4 receptors

    L. Donlon, A. Peñaherrera and D. Frankel, Soft Matter, 2013, 9, 2803
    DOI: 10.1039/C2SM27387J

Search articles by author

Spotlight

Advertisements