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Issue 11, 2013
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Prediction of suitable catalyst by 1H NMR: asymmetric synthesis of multisubstituted biaryls by chiral phosphoric acid catalyzed asymmetric bromination

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Abstract

We describe herein the “1H NMR-assisted catalyst screening method,” which enables us to find the suitable catalyst easily and predict enantioselectivity with the same accuracy as the computational method. Based on this method, we constructed multisubstituted biaryls that occur frequently in many biologically active compounds, chiral ligands, and organocatalysts, with excellent enantioselectivities via chiral phosphoric acid-catalyzed asymmetric bromination.

Graphical abstract: Prediction of suitable catalyst by 1H NMR: asymmetric synthesis of multisubstituted biaryls by chiral phosphoric acid catalyzed asymmetric bromination

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Publication details

The article was received on 01 Aug 2013, accepted on 06 Aug 2013 and first published on 09 Aug 2013


Article type: Edge Article
DOI: 10.1039/C3SC52142G
Citation: Chem. Sci., 2013,4, 4235-4239
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    Prediction of suitable catalyst by 1H NMR: asymmetric synthesis of multisubstituted biaryls by chiral phosphoric acid catalyzed asymmetric bromination

    K. Mori, Y. Ichikawa, M. Kobayashi, Y. Shibata, M. Yamanaka and T. Akiyama, Chem. Sci., 2013, 4, 4235
    DOI: 10.1039/C3SC52142G

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