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Issue 9, 2013
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1,2,3-Triazoles as versatile directing group for selective sp2 and sp3 C–H activation: cyclization vs substitution

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Abstract

Selective cyclization and substitution was achieved with designated 1,2,3-triazole acid auxiliary groups under Pd catalyzed C–H activation conditions. Both sp2 and sp3 C–H bonds were effectively activated, giving the desired products in good yields. This result revealed the first successful example of exclusive substitution using 1,2,3-triazole ligands, while another triazole-containing directing group dominantly gave cyclization under identical conditions.

Graphical abstract: 1,2,3-Triazoles as versatile directing group for selective sp2 and sp3 C–H activation: cyclization vs substitution

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Publication details

The article was received on 03 May 2013, accepted on 02 Jul 2013 and first published on 02 Jul 2013


Article type: Edge Article
DOI: 10.1039/C3SC51211H
Citation: Chem. Sci., 2013,4, 3712-3716
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    1,2,3-Triazoles as versatile directing group for selective sp2 and sp3 C–H activation: cyclization vs substitution

    X. Ye, Z. He, T. Ahmed, K. Weise, N. G. Akhmedov, J. L. Petersen and X. Shi, Chem. Sci., 2013, 4, 3712
    DOI: 10.1039/C3SC51211H

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