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Issue 14, 2014
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Nanodomain cubic cuprous oxide as reusable catalyst in one-pot synthesis of 3-alkyl/aryl-3-(pyrrole-2-yl/indole-3-yl)-2-phenyl-2,3-dihydro-isoindolinones in aqueous medium

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Abstract

An environmentally benign one-pot protocol has been developed for the syntheses of 3-alkyl/aryl-3-(pyrrole/indole-2/3-yl)-2-phenyl-2,3-dihydro-isoindolinones via a multi-component one-pot reaction involving 2-iodo-N-phenylbenzamides, terminal alkyne and substituted indoles/pyrroles in aqueous medium using cubic cuprous oxide nanoparticles as catalyst. It involves domino Sonogashira-5-exo-dig-cyclization followed by regioselective nucleophilic addition of indoles or pyrroles, in aqueous medium without using any surfactants or additional ligands.

Graphical abstract: Nanodomain cubic cuprous oxide as reusable catalyst in one-pot synthesis of 3-alkyl/aryl-3-(pyrrole-2-yl/indole-3-yl)-2-phenyl-2,3-dihydro-isoindolinones in aqueous medium

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Publication details

The article was received on 28 Oct 2013, accepted on 24 Dec 2013 and first published on 03 Jan 2014


Article type: Communication
DOI: 10.1039/C3RA46168H
Citation: RSC Adv., 2014,4, 7024-7029
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    Nanodomain cubic cuprous oxide as reusable catalyst in one-pot synthesis of 3-alkyl/aryl-3-(pyrrole-2-yl/indole-3-yl)-2-phenyl-2,3-dihydro-isoindolinones in aqueous medium

    S. Sarkar, N. Chatterjee, M. Roy, R. Pal, S. Sarkar and A. K. Sen, RSC Adv., 2014, 4, 7024
    DOI: 10.1039/C3RA46168H

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