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Issue 45, 2013
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Investigation and folding pattern of L-ido and D-gluco peptides by EASY ROESY NMR and X-ray

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Abstract

The sugar β-amino acid plays an important role in the formation of well-defined secondary structures of peptides. The combination of change in the functional group, stereocenter on the sugar amino acid and peptide attachment to the glycopeptide revealed important information about their secondary structure. The stereocentre (C5–H) of the sugar β-amino acid in these peptidic diastereomers controls the folding behaviour of these compounds. Conformations of the considered compounds were established by NMR (EASY-ROESY) and compared with the 3D structure obtained from X-ray crystallography.

Graphical abstract: Investigation and folding pattern of l-ido and d-gluco peptides by EASY ROESY NMR and X-ray

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Publication details

The article was received on 21 Aug 2013, accepted on 30 Sep 2013 and first published on 01 Oct 2013


Article type: Paper
DOI: 10.1039/C3RA44542A
Citation: RSC Adv., 2013,3, 23355-23360
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    Investigation and folding pattern of L-ido and D-gluco peptides by EASY ROESY NMR and X-ray

    S. A. Pawar, A. M. Jabgunde, K. Petzold, G. E. M. Maguire, D. D. Dhavale, H. G. Kruger and T. Govender, RSC Adv., 2013, 3, 23355
    DOI: 10.1039/C3RA44542A

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