Issue 40, 2013
From the journal:

RSC Advances

Chiral boron Lewis acid-catalyzed asymmetric synthesis of 4,5-dihydropyrrolo[1,2-a]quinoxalines†

Yuan Li,a   Yu-Han Su,a   De-Jun Dong,a   Zhao Wua  and  Shi-Kai Tian*ab  

* Corresponding authors

a Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China
E-mail: tiansk@ustc.edu.cn
Fax: (+86) 551-6360-1592
Tel: (+86) 551-6360-0871

b Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

Abstract

In the presence of B(OMe)3/(R)-BINOL (1 : 1, 10 mol%) and 4 Å molecular sieves, a range of 2-(1H-pyrrol-1-yl)anilines smoothly underwent a Pictet–Spengler-type reaction with aldehydes to give structurally diverse 4,5-dihydropyrrolo[1,2-a]quinoxalines in good to excellent yields and ee.

Graphical abstract: Chiral boron Lewis acid-catalyzed asymmetric synthesis of 4,5-dihydropyrrolo[1,2-a]quinoxalines

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Article information

DOI
https://doi.org/10.1039/C3RA43248C
Article type
Communication
Submitted
27 Jun 2013
Accepted
30 Jul 2013
First published
07 Aug 2013

RSC Adv., 2013,3, 18275-18278

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Chiral boron Lewis acid-catalyzed asymmetric synthesis of 4,5-dihydropyrrolo[1,2-a]quinoxalines

Y. Li, Y. Su, D. Dong, Z. Wu and S. Tian, RSC Adv., 2013, 3, 18275 DOI: 10.1039/C3RA43248C

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