Issue 36, 2013
From the journal:

RSC Advances

General and efficient copper-catalyzed aerobic oxidative synthesis of N-fused heterocycles using amino acids as the nitrogen source†

Qing Liu,a   Haijun Yang,a   Yuyang Jiang,b   Yufen Zhaoa  and  Hua Fu*ab  

* Corresponding authors

a Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China
E-mail: fuhua@mail.tsinghua.edu.cn

b Key Laboratory of Chemical Biology (Guangdong Province), Graduate School of Shenzhen, Tsinghua University, Shenzhen 518057, P. R. China

Abstract

A general and efficient copper-catalyzed aerobic oxidative method for the synthesis of N-fused heterocycles has been developed by using readily available α-amino acids as the nitrogen source. The reactions underwent N-arylation, aerobic oxidative dehydrogenation, intramolecular cyclization and dissociation of formic acid. This method should provide a general and practical strategy for the construction of N-fused heterocycles.

Graphical abstract: General and efficient copper-catalyzed aerobic oxidative synthesis of N-fused heterocycles using amino acids as the nitrogen source

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Article information

DOI
https://doi.org/10.1039/C3RA41644E
Article type
Paper
Submitted
05 Apr 2013
Accepted
28 Jun 2013
First published
01 Jul 2013

RSC Adv., 2013,3, 15636-15644

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General and efficient copper-catalyzed aerobic oxidative synthesis of N-fused heterocycles using amino acids as the nitrogen source

Q. Liu, H. Yang, Y. Jiang, Y. Zhao and H. Fu, RSC Adv., 2013, 3, 15636 DOI: 10.1039/C3RA41644E

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