Issue 24, 2013
From the journal:

RSC Advances

Enantioselective Strecker-type reaction between azomethineimines and trimethylsilyl cyanide catalyzed by a cinchona alkaloid-derived thiourea bearing multiple hydrogen-bonding donors†

Nai-Kai Li,a   Zhao-Min Liu,a   Xiao-Fei Huang,a   Jin-Xin Zhang,a   Xiang Chen,a   Yong Wang*a  and  Xing-Wang Wang*a  

* Corresponding authors

a Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China
E-mail: yowang@suda.edu.cn, wangxw@suda.edu.cn

Abstract

The asymmetric Strecker-type reaction between azomethine imines and TMSCN was catalyzed by 1 mol% of a cinchona alkaloid-derived thiourea bearing multiple hydrogen-bonding donors to afford optically active amino nitriles in good to excellent yields and enantioselectivities.

Graphical abstract: Enantioselective Strecker-type reaction between azomethine imines and trimethylsilyl cyanide catalyzed by a cinchona alkaloid-derived thiourea bearing multiple hydrogen-bonding donors

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Article information

DOI
https://doi.org/10.1039/C3RA41640B
Article type
Communication
Submitted
27 Feb 2013
Accepted
23 Apr 2013
First published
23 Apr 2013

RSC Adv., 2013,3, 9154-9157

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Enantioselective Strecker-type reaction between azomethine imines and trimethylsilyl cyanide catalyzed by a cinchona alkaloid-derived thiourea bearing multiple hydrogen-bonding donors

N. Li, Z. Liu, X. Huang, J. Zhang, X. Chen, Y. Wang and X. Wang, RSC Adv., 2013, 3, 9154 DOI: 10.1039/C3RA41640B

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