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Issue 20, 2013
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A novel antimicrobial agent reduces oxidative stress in cells

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Abstract

1,3,5-Tris[(1E)-2′-(4′′-benzoic acid)vinyl]benzene] (Ramizol™) is a potent and non-toxic synthetic antimicrobial agent, and we now establish that it is also a potent inhibitor of reactive oxygen species (ROS) generation, with similar antioxidant activity to α-tocopherol (Vitamin E), which is a standard antioxidantdrug. The results show that Ramizol™ decreases ROS to basal levels in PC12 cells and mouse and guinea pig myocytes, and demonstrate its protective nature from oxidative damage to the cells. The continuing challenge to discover antibiotics with no or few side effects makes Ramizol™ a very attractive candidate for the potential treatment of infections.

Graphical abstract: A novel antimicrobial agent reduces oxidative stress in cells

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Publication details

The article was received on 06 Feb 2013, accepted on 21 Mar 2013 and first published on 21 Mar 2013


Article type: Communication
DOI: 10.1039/C3RA40658J
Citation: RSC Adv., 2013,3, 7277-7281
  • Open access: Creative Commons BY license
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    A novel antimicrobial agent reduces oxidative stress in cells

    E. James, H. Viola, L. Hool, P. K. Eggers, C. L. Raston and R. A. Boulos, RSC Adv., 2013, 3, 7277
    DOI: 10.1039/C3RA40658J

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