Issue 26, 2013
From the journal:

RSC Advances

Cu-Catalyzed alkynylation–cyclization cascade for the construction of the pyrazolo[5,1-a]isoquinoline skeleton†

Yanfang Yang,a   Hailong Ren,a   Dongyang Wang,a   Feng Shi*a  and  Chunrui Wu*a  

* Corresponding authors

a Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University, Jinming Campus, Kaifeng, Henan 475004, China PR
E-mail: fshi@henu.edu.cn, cwu@henu.edu.cn
Fax: +(86)-378-2864665
Tel: +(86)-378-2864665

Abstract

A Cu-catalyzed Sonogashira-type coupling of 3-(2-bromophenyl)pyrazoles with terminal alkynes combined with a subsequent electrophilic cyclization in the same pot was developed to afford pyrazolo[5,1-a]isoquinolines. The transformation proceeds without the necessity of using Pd or ligands, while an Ag additive is beneficial.

Graphical abstract: Cu-Catalyzed alkynylation–cyclization cascade for the construction of the pyrazolo[5,1-a]isoquinoline skeleton

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Article information

DOI
https://doi.org/10.1039/C3RA40270C
Article type
Paper
Submitted
17 Jan 2013
Accepted
10 Apr 2013
First published
11 Apr 2013

RSC Adv., 2013,3, 10434-10441

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Cu-Catalyzed alkynylation–cyclization cascade for the construction of the pyrazolo[5,1-a]isoquinoline skeleton

Y. Yang, H. Ren, D. Wang, F. Shi and C. Wu, RSC Adv., 2013, 3, 10434 DOI: 10.1039/C3RA40270C

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