Issue 11, 2013
From the journal:

RSC Advances

Unexpectedly large water-proton relaxivity of TEMPO incorporated into micelle-oligonucleotides†

Emi Tanimoto,a   Satoru Karasawa,a   Shoji Ueki,b   Nobuhiro Nitta,c   Ichio Aokic  and  Noboru Koga*a  

* Corresponding authors

a Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
E-mail: koga@fc.phar.kyushu-u.ac.jp
Fax: 81-92-642-6590
Tel: 81-92-642-6590

b Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, 1314-1 Shido, Kagawa 769-2101, Sanuki, Japan
E-mail: ueki@kph.bunri-u.ac.jp

c Molecular Imaging Center, National Institute of Radiologic Sciences (NIRS), 4-9-1 Anagawa, Inage, Chiba 263-8555, Japan
E-mail: aoki@nirs.go.jp

Abstract

Three lipid-oligonucleotides (ODN) carrying TEMPO were prepared and formed a micelle with a diameter of ca. 10 nm. The double strand ODN, lipid-polyTinDS, incorporating TEMPO near the core of the micelle showed the largest water-proton relaxivity, r1, value of 2.4 (25 MHz, 0.59 T) and 6.8 mM−1 s−1 (42 MHz, 1.0 T) per TEMPO.

Graphical abstract: Unexpectedly large water-proton relaxivity of TEMPO incorporated into micelle-oligonucleotides

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Article information

DOI
https://doi.org/10.1039/C3RA22372H
Article type
Communication
Submitted
02 Oct 2012
Accepted
21 Jan 2013
First published
23 Jan 2013

RSC Adv., 2013,3, 3531-3534

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Unexpectedly large water-proton relaxivity of TEMPO incorporated into micelle-oligonucleotides

E. Tanimoto, S. Karasawa, S. Ueki, N. Nitta, I. Aoki and N. Koga, RSC Adv., 2013, 3, 3531 DOI: 10.1039/C3RA22372H

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