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Issue 9, 2013
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A non-isothiocyanate route to synthesize trisubstituted thioureas of arylamines using in situ generated dithiocarbamates

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Abstract

A novel, user-friendly, and convenient method for the synthesis of trisubstituted thioureas of arylamines is presented, for the first time, using in situ generated dithiocarbamates of secondary amines. This strategy provides an excellent opportunity to access thioureas containing primary aryl amines. A non-isothiocyanate route to obtain thioureas is the advantage of this strategy, which may provide a useful route to synthesize a variety of biologically active derivatives of thioureas.

Graphical abstract: A non-isothiocyanate route to synthesize trisubstituted thioureas of arylamines using in situ generated dithiocarbamates

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Publication details

The article was received on 14 Sep 2012, accepted on 12 Dec 2012 and first published on 12 Dec 2012


Article type: Paper
DOI: 10.1039/C2RA23257J
Citation: RSC Adv., 2013,3, 3079-3087
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    A non-isothiocyanate route to synthesize trisubstituted thioureas of arylamines using in situ generated dithiocarbamates

    B. V. Varun and K. R. Prabhu, RSC Adv., 2013, 3, 3079
    DOI: 10.1039/C2RA23257J

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