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Issue 4, 2013
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Direct synthesis of 8-aryl tetrahydroquinolines via pd-catalyzed ortho-arylation of aryl ureas in water

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Abstract

An efficient protocol for the direct synthesis of 8-arylated tetrahydroquinolines via Pd-catalyzed ortho-arylation of aryl ureas with aryl iodides was developed. The reaction proceeded smoothly in water under ligand-free and surfactant-free conditions, providing the desired products in high yields with remarkable functional group tolerance.

Graphical abstract: Direct synthesis of 8-aryl tetrahydroquinolines via pd-catalyzed ortho-arylation of aryl ureas in water

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Publication details

The article was received on 14 Nov 2012, accepted on 15 Nov 2012 and first published on 15 Nov 2012


Article type: Communication
DOI: 10.1039/C2RA22901C
Citation: RSC Adv., 2013,3, 1025-1028
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    Direct synthesis of 8-aryl tetrahydroquinolines via pd-catalyzed ortho-arylation of aryl ureas in water

    Z. Jiang, L. Zhang, C. Dong, X. Su, H. Li, W. Tang, L. Xu and Q. Fan, RSC Adv., 2013, 3, 1025
    DOI: 10.1039/C2RA22901C

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