Issue 6, 2013
From the journal:

RSC Advances

Oligo switches: photoresponsive oligonucleotide conjugates by solid-supported click chemistry†‡

Colin Freeman,*a   Joseph S. Vyleb  and  Frances Heaney*a  

* Corresponding authors

a Dept. of Chemistry, National University of Ireland, Maynooth, Co. Kildare, Ireland
E-mail: mary.f.heaney@nuim.ie
Fax: +353 1708 3815
Tel: +353 1708 3802

b School of Chemistry and Chemical Engineering, Queen's University Belfast, David Keir Building, Stranmillis Road, Belfast BT95AG
E-mail: j.vyle@qub.ac.uk
Fax: (+44) 28-9097-6524

Abstract

Photoresponsive oligonucleotides (ONs) incorporating isoxazole-linked azobenzene (AB) moieties were prepared by resin-supported nitrile oxide-alkyne cycloaddition (NOAC) chemistry. The thermal and photochromic properties of the modified ONs were significantly influenced by the extent of π-conjugation between the isoxazole and the AB modules.

Graphical abstract: Oligo switches: photoresponsive oligonucleotide conjugates by solid-supported click chemistry

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Article information

DOI
https://doi.org/10.1039/C2RA22815G
Article type
Communication
Submitted
08 Nov 2012
Accepted
20 Nov 2012
First published
11 Dec 2012

RSC Adv., 2013,3, 1652-1655

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Oligo switches: photoresponsive oligonucleotide conjugates by solid-supported click chemistry

C. Freeman, J. S. Vyle and F. Heaney, RSC Adv., 2013, 3, 1652 DOI: 10.1039/C2RA22815G

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