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Issue 1, 2013
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Acceleration of the Eschenmoser coupling reaction by sonication: efficient synthesis of enaminones

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Abstract

Enaminones are commonly prepared by the Eschenmoser coupling reaction. The duration of the reaction is often long. Here, we describe how sonication can accelerate this reaction. The reaction conditions provide an efficient method for the coupling of primary, secondary and tertiary thioamides with α-bromocarbonyl compounds.

Graphical abstract: Acceleration of the Eschenmoser coupling reaction by sonication: efficient synthesis of enaminones

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Publication details

The article was received on 03 Sep 2012, accepted on 08 Oct 2012 and first published on 14 Nov 2012


Article type: Paper
DOI: 10.1039/C2RA22033D
Citation: RSC Adv., 2013,3, 181-188
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    Acceleration of the Eschenmoser coupling reaction by sonication: efficient synthesis of enaminones

    N. D. Koduri, B. Hileman, J. D. Cox, H. Scott, P. Hoang, A. Robbins, K. Bowers, L. Tsebaot, K. Miao, M. Castaneda, M. Coffin, G. Wei, T. D. W. Claridge, K. P. Roberts and S. R. Hussaini, RSC Adv., 2013, 3, 181
    DOI: 10.1039/C2RA22033D

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