Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 39, 2013
Previous Article Next Article

A three step continuous flow synthesis of the biaryl unit of the HIV protease inhibitorAtazanavir

Author affiliations

Abstract

The development of multistep continuous flow reactions for the synthesis of important intermediates for the pharmaceutical industry is still a significant challenge. In the present contribution the biaryl-hydrazine unit of Atazanavir, an important HIV protease inhibitor, was prepared in a three-step continuous flow sequence in 74% overall yield. The synthesis involved Pd-catalyzed Suzuki–Miyaura cross-coupling, followed by hydrazone formation and a subsequent hydrogenation step, and additionally incorporates a liquid–liquid extraction step.

Graphical abstract: A three step continuous flow synthesis of the biaryl unit of the HIV protease inhibitorAtazanavir

Back to tab navigation
Please wait while Download options loads

Publication details

The article was received on 16 Jul 2013, accepted on 12 Aug 2013 and first published on 14 Aug 2013


Article type: Paper
DOI: 10.1039/C3OB41464G
Citation: Org. Biomol. Chem., 2013,11, 6806-6813
  • Open access: Creative Commons BY-NC license
  •   Request permissions

    A three step continuous flow synthesis of the biaryl unit of the HIV protease inhibitorAtazanavir

    L. Dalla-Vechia, B. Reichart, T. Glasnov, L. S. M. Miranda, C. O. Kappe and R. O. M. A. de Souza, Org. Biomol. Chem., 2013, 11, 6806
    DOI: 10.1039/C3OB41464G

Search articles by author