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Issue 38, 2013
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A facile total synthesis of drospirenone isomers containing 14β-hydrogen configuration

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Abstract

A facile strategy for the preparation of two isomeric drospirenones 13 and 16 possessing a 14β-hydrogen was developed, using 3β-hydroxyandrost-5-en-17-one as the starting material. The total synthetic route involves eight steps, giving 2% overall yield. The structures of the main compounds 11, 13, 14 and 16 were determined by single crystal XRD analysis.

Graphical abstract: A facile total synthesis of drospirenone isomers containing 14β-hydrogen configuration

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Publication details

The article was received on 14 Jun 2013, accepted on 03 Aug 2013 and first published on 07 Aug 2013


Article type: Paper
DOI: 10.1039/C3OB41211C
Citation: Org. Biomol. Chem., 2013,11, 6597-6603
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    A facile total synthesis of drospirenone isomers containing 14β-hydrogen configuration

    W. Wan, G. Ma, W. Gao, J. Wang, L. Li, S. Rao, C. Zheng, H. Jiang, H. Deng and J. Hao, Org. Biomol. Chem., 2013, 11, 6597
    DOI: 10.1039/C3OB41211C

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