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Issue 19, 2013
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Synthesis of the IGF-II-like hormone vesiculin using regioselective formation of disulfide bonds

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Abstract

Diabetes mellitus, characterised by hyperglycemia and altered β-cell function, is an increasingly common disorder affecting millions of individuals world-wide. While therapeutic regimens exist to manage the condition, diabetic individuals remain prone to complications that are detrimental to both their length and quality of life. An improved understanding of the disease which may then enable development of new treatments is therefore a desirable goal. Vesiculin, a novel IGF-II-like protein was recently isolated from the secretory granules of murine β-cells, and preliminary studies indicate it is capable of signalling via the insulin receptor (IR)/insulin-like growth factor receptor 1(IGF1R) family giving it the potential to elicit both metabolic and mitogenic responses in the beta-cell. In order to facilitate further studies on this new member of the insulin-family of hormones, we undertook a chemical synthesis of the protein using regioselective disulfide bond formation.

Graphical abstract: Synthesis of the IGF-II-like hormone vesiculin using regioselective formation of disulfide bonds

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Publication details

The article was received on 13 Feb 2013, accepted on 21 Mar 2013 and first published on 22 Mar 2013


Article type: Paper
DOI: 10.1039/C3OB40322J
Citation: Org. Biomol. Chem., 2013,11, 3145-3150
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    Synthesis of the IGF-II-like hormone vesiculin using regioselective formation of disulfide bonds

    G. M. Williams, G. J. S. Cooper, K. Lee, L. Whiting and M. A. Brimble, Org. Biomol. Chem., 2013, 11, 3145
    DOI: 10.1039/C3OB40322J

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