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Issue 26, 2013
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Highly specific, multi-branched fluorescent reporters for analysis of human neutrophil elastase

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Abstract

Human neutrophil elastase (HNE) is a serine protease implicated in the pathogenesis of acute and chronic inflammatory disease. Here a series of, internally quenched, single fluorophore fluorescent reporters were synthesised that allowed the rapid, highly specific and sensitive analysis of HNE activity over closely related proteases.

Graphical abstract: Highly specific, multi-branched fluorescent reporters for analysis of human neutrophil elastase

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Publication details

The article was received on 30 Jan 2013, accepted on 29 Apr 2013 and first published on 01 May 2013


Article type: Paper
DOI: 10.1039/C3OB40212F
Citation: Org. Biomol. Chem., 2013,11, 4414-4418
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    Highly specific, multi-branched fluorescent reporters for analysis of human neutrophil elastase

    N. Avlonitis, M. Debunne, T. Aslam, N. McDonald, C. Haslett, K. Dhaliwal and M. Bradley, Org. Biomol. Chem., 2013, 11, 4414
    DOI: 10.1039/C3OB40212F

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