Issue 12, 2013

Stereoselective synthesis of N-heterocycles through amine addition to nitroalkenes

Abstract

An efficient route for the preparation of substituted N-heterocycles was developed through the amine addition to nitroalkenes. The reaction tolerates a large substrate scope with good to excellent yields (up to 95%) and excellent stereoselectivities (up to 99 : 1 dr).

Graphical abstract: Stereoselective synthesis of N-heterocycles through amine addition to nitroalkenes

Supplementary files

Article information

Article type
Communication
Submitted
18 Dec 2012
Accepted
25 Jan 2013
First published
28 Jan 2013

Org. Biomol. Chem., 2013,11, 1917-1920

Stereoselective synthesis of N-heterocycles through amine addition to nitroalkenes

L. N. Gautam, Q. Wang, N. G. Akhmedov, J. L. Petersen and X. Shi, Org. Biomol. Chem., 2013, 11, 1917 DOI: 10.1039/C3OB27452G

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