Jump to main content
Jump to site search

Issue 6, 2013
Previous Article Next Article

Development of a benzophenone and alkyne functionalised trehalose probe to study trehalose dimycolate binding proteins

Author affiliations

Abstract

Trehalose dimycolates (TDMs) are the most abundant glycolipids found in the cell wall of Mycobacterium tuberculosis (M. tb). TDMs play an important role in the pathogenesis of M. tb yet the only known receptor for TDM is the macrophage inducible C-type lectin (mincle). To understand more about the interaction of TDMs with immune cells, affinity based proteome profiling (AfBPP) can be used to determine receptors that bind TDMs. To this end, we present the synthesis of the first AfBPP-TDM probe and report on its ability to activate macrophages. By doing so, we establish that the AfBPP-TDM probe appears to be a suitable substrate for future proteomic profiling experiments.

Graphical abstract: Development of a benzophenone and alkyne functionalised trehalose probe to study trehalose dimycolate binding proteins

Back to tab navigation

Supplementary files

Publication details

The article was received on 20 Nov 2012, accepted on 06 Dec 2012 and first published on 11 Dec 2012


Article type: Communication
DOI: 10.1039/C2OB27257A
Citation: Org. Biomol. Chem., 2013,11, 881-885
  •   Request permissions

    Development of a benzophenone and alkyne functionalised trehalose probe to study trehalose dimycolate binding proteins

    A. A. Khan, F. Kamena, M. S. M. Timmer and B. L. Stocker, Org. Biomol. Chem., 2013, 11, 881
    DOI: 10.1039/C2OB27257A

Search articles by author

Spotlight

Advertisements