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Issue 4, 2013
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The conversion of [(4-chloro-5H-1,2,3-dithiazol-5-ylidene)amino]azines into azine fused thiazole-2-carbonitriles

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Abstract

The thermolysis of several N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)pyridin-n-amines (where n = 2, 3 and 4) gives a mixture of thiazolopyridine-2-carbonitriles in low to moderate yields. Introduction, by design, of a chlorine substituent at the C2 or C4 position of N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)pyridin-3-amine and other selected azines enables a BnEt3NI mediated ANRORC style ring transformation that provides fourteen heteroazine fused thiazole-2-carbonitriles in moderate to near quantitative yields. The synthesis described herein therefore provides a facile high yielding two-step route to heteroazine fused thiazole-2-carbonitriles starting from 4,5-dichloro-1,2,3-dithiazolium chloride (Appel salt) and ortho- or para-chloro substituted meta-aminoazines.

Graphical abstract: The conversion of [(4-chloro-5H-1,2,3-dithiazol-5-ylidene)amino]azines into azine fused thiazole-2-carbonitriles

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Publication details

The article was received on 12 Oct 2012, accepted on 22 Nov 2012 and first published on 22 Nov 2012


Article type: Paper
DOI: 10.1039/C2OB26993G
Citation: Org. Biomol. Chem., 2013,11, 621-629
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    The conversion of [(4-chloro-5H-1,2,3-dithiazol-5-ylidene)amino]azines into azine fused thiazole-2-carbonitriles

    P. A. Koutentis, M. Koyioni and S. S. Michaelidou, Org. Biomol. Chem., 2013, 11, 621
    DOI: 10.1039/C2OB26993G

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