Jump to main content
Jump to site search

Issue 4, 2014
Previous Article Next Article

Photocleavage control of nucleated DNA nanosystems – the influence of surface strand sterics

Author affiliations

Abstract

We use sterically inaccessible ‘seed’ strands, released from a surface into solution by photocleavage to initiate a nucleated DNA polymerization reaction. We demonstrate control of the quantity of ‘seed’ release and that hairpin steric protection of the ‘seed’ leads to less ‘leaky’ surfaces. This polymerization is a model system for surface-photocleavage initiation of sub-stoichiometric reaction cascades; these cascades should find use as a component of labs-on-chips capable of bioanalytical and DNA-computing tasks.

Graphical abstract: Photocleavage control of nucleated DNA nanosystems – the influence of surface strand sterics

Back to tab navigation

Supplementary files

Publication details

The article was received on 04 Nov 2013, accepted on 17 Dec 2013 and first published on 20 Dec 2013


Article type: Communication
DOI: 10.1039/C3NR05875A
Author version available: Download Author version (PDF)
Citation: Nanoscale, 2014,6, 2094-2096
  •   Request permissions

    Photocleavage control of nucleated DNA nanosystems – the influence of surface strand sterics

    M. Hanna, M. Munshi, N. A. Kedzierski, P. N. Chung, T. Huang, A. K. Mok and P. S. Lukeman, Nanoscale, 2014, 6, 2094
    DOI: 10.1039/C3NR05875A

Search articles by author

Spotlight

Advertisements