FITC–quencher based caspase 3-activatable nanoprobes for effectively sensing caspase 3 in vitro and in cells

Anming Tang; Bin Mei; Weijuan Wang; Wanglai Hu; Fang Li; Jun Zhou; Qing Yang; Hua Cui; Mian Wu; Gaolin Liang

doi:10.1039/C3NR03339B

FITC–quencher based caspase 3-activatable nanoprobes for effectively sensing caspase 3 in vitro and in cells†

Anming Tang,^a Bin Mei,^a Weijuan Wang,^a Wanglai Hu,^b Fang Li,^a Jun Zhou,^a Qing Yang,^a Hua Cui,^a Mian Wu^b and Gaolin Liang*^a

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^a CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, China
E-mail: gliang@ustc.edu.cn
Fax: +86-551-6360-0730
Tel: +86-551-6360-7935

^b School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China

Abstract

By employing fluorescence resonance energy transfer (FRET) quenching, we rationally designed two new FITC–quencher based nanoprobes for effectively sensing caspase 3 (Casp3) in vitro and in cells. Our nanoprobes hold promise for assessing the chemotherapeutic effect of cancer treatment.

Nanoscale

FITC–quencher based caspase 3-activatable nanoprobes for effectively sensing caspase 3 in vitro and in cells†

Abstract

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FITC–quencher based caspase 3-activatable nanoprobes for effectively sensing caspase 3 in vitro and in cells

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