Issue 19, 2013

Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles

Abstract

RBC membrane-cloaked polymeric nanoparticles represent an emerging nanocarrier platform with extended circulation in vivo. A lipid-insertion method is employed to functionalize these nanoparticles without the need for direct chemical conjugation. Insertion of both folate and the nucleolin-targeting aptamer AS1411 shows receptor-specific targeting against model cancer cell lines.

Graphical abstract: Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles

Supplementary files

Article information

Article type
Communication
Submitted
14 Jun 2013
Accepted
17 Jul 2013
First published
19 Jul 2013
This article is Open Access
Creative Commons BY license

Nanoscale, 2013,5, 8884-8888

Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles

R. H. Fang, C. J. Hu, K. N. H. Chen, B. T. Luk, C. W. Carpenter, W. Gao, S. Li, D. Zhang, W. Lu and L. Zhang, Nanoscale, 2013, 5, 8884 DOI: 10.1039/C3NR03064D

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements