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Issue 19, 2013
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Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles

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Abstract

RBC membrane-cloaked polymeric nanoparticles represent an emerging nanocarrier platform with extended circulation in vivo. A lipid-insertion method is employed to functionalize these nanoparticles without the need for direct chemical conjugation. Insertion of both folate and the nucleolin-targeting aptamer AS1411 shows receptor-specific targeting against model cancer cell lines.

Graphical abstract: Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles

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Publication details

The article was received on 14 Jun 2013, accepted on 17 Jul 2013 and first published on 19 Jul 2013


Article type: Communication
DOI: 10.1039/C3NR03064D
Citation: Nanoscale, 2013,5, 8884-8888
  • Open access: Creative Commons BY license
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    Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles

    R. H. Fang, C. J. Hu, K. N. H. Chen, B. T. Luk, C. W. Carpenter, W. Gao, S. Li, D. Zhang, W. Lu and L. Zhang, Nanoscale, 2013, 5, 8884
    DOI: 10.1039/C3NR03064D

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