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Issue 20, 2013
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Janus nanogels of PEGylated Taxol and PLGA–PEG–PLGA copolymer for cancer therapy

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Abstract

Nanogels are promising carriers for the delivery of anti-cancer drugs for cancer therapy. We report in this study on a Janus nanogel system formed by mixing a prodrug of Taxol (PEGylated Taxol) and a copolymer of PLGA–PEG–PLGA. The Janus nanogels have good stability over months in aqueous solutions and the freeze-dried powder of nanogels can be re-dispersed instantly in aqueous solutions. The Janus nanogels show an enhanced inhibition effect on tumor growth in a mice breast cancer model probably due to the enhanced uptake of the nano-sized materials by the EPR effect. What is more, the nanogels can also serve as physical carriers to co-deliver other anti-cancer drugs such as doxorubicin to further improve the anti-cancer efficacy. The results obtained from H&E staining and TUNEL assay also support the observation of tumor growth inhibition. These results suggest the potential of this novel delivery system for cancer therapy.

Graphical abstract: Janus nanogels of PEGylated Taxol and PLGA–PEG–PLGA copolymer for cancer therapy

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Publication details

The article was received on 06 Jun 2013, accepted on 31 Jul 2013 and first published on 08 Aug 2013


Article type: Paper
DOI: 10.1039/C3NR02937A
Citation: Nanoscale, 2013,5, 9902-9907
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    Janus nanogels of PEGylated Taxol and PLGA–PEG–PLGA copolymer for cancer therapy

    J. Wei, H. Wang, M. Zhu, D. Ding, D. Li, Z. Yin, L. Wang and Z. Yang, Nanoscale, 2013, 5, 9902
    DOI: 10.1039/C3NR02937A

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