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Issue 30, 2013
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An ultrasensitive chemiluminescence turn-on assay for protease and inhibitor screening with a natural substrate

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Abstract

A highly sensitive and convenient chemiluminescence (CL) turn-on assay for protease without any label and synthesis has been developed. Cytochrome c was digested by a protease, and heme was released as a peptideheme conjugate, which greatly enhanced the luminol–H2O2 CL reaction.

Graphical abstract: An ultrasensitive chemiluminescence turn-on assay for protease and inhibitor screening with a natural substrate

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Publication details

The article was received on 02 Feb 2013, accepted on 01 Mar 2013 and first published on 04 Mar 2013


Article type: Communication
DOI: 10.1039/C3CC40906F
Citation: Chem. Commun., 2013,49, 3137-3139
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    An ultrasensitive chemiluminescence turn-on assay for protease and inhibitor screening with a natural substrate

    Q. Zhang, W. Li, J. Chen, F. Wang, Y. Wang, Y. Chen and C. Yu, Chem. Commun., 2013, 49, 3137
    DOI: 10.1039/C3CC40906F

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