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Issue 24, 2013
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Light uncages a copper complex to induce nonapoptotic cell death

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Abstract

Cu3G is a Cu(II) complex of a photoactive tetradentate ligand that is cleaved upon UV irradiation to release Cu. Here we show that the cytotoxicity of Cu3G increases in response to brief UV stimulation to result in extensive cytoplasmic vacuolization that is indicative of nonapoptotic cell death.

Graphical abstract: Light uncages a copper complex to induce nonapoptotic cell death

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Publication details

The article was received on 13 Dec 2012, accepted on 04 Feb 2013, published on 15 Feb 2013 and first published online on 15 Feb 2013


Article type: Communication
DOI: 10.1039/C3CC38927H
Citation: Chem. Commun., 2013,49, 2460-2462
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    Light uncages a copper complex to induce nonapoptotic cell death

    A. A. Kumbhar, A. T. Franks, R. J. Butcher and K. J. Franz, Chem. Commun., 2013, 49, 2460
    DOI: 10.1039/C3CC38927H

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