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Issue 3, 2013
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Polycyclic xanthone natural products: structure, biological activity and chemical synthesis

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Abstract

Covering: 1972 to 2012

Polycyclic xanthone natural products are a family of polyketides which are characterized by highly oxygenated, angular hexacyclic frameworks. In the last decade, this novel class of molecules has attracted noticeable attention from the synthetic and biological communities due to emerging reports of their potential use as antitumour agents. The aim of this article is to highlight the most recent developments of this subset of the xanthone family by detailing the innate challenges of the construction of this class of natural products, new synthetic approaches, and pharmacological data.

Graphical abstract: Polycyclic xanthone natural products: structure, biological activity and chemical synthesis

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Publication details

The article was received on 04 Dec 2012 and first published on 21 Jan 2013


Article type: Highlight
DOI: 10.1039/C3NP20122H
Citation: Nat. Prod. Rep., 2013,30, 382-391
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    Polycyclic xanthone natural products: structure, biological activity and chemical synthesis

    D. K. Winter, D. L. Sloman and J. A. Porco Jr., Nat. Prod. Rep., 2013, 30, 382
    DOI: 10.1039/C3NP20122H

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