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Department of Chemistry, Center for Chemical Methodology and Library Development (CMLD-BU), Boston University, 590 Commonwealth Avenue, Boston, USA
E-mail: porco@bu.edu
; Fax: (+1) 617-358-2847
; Tel: (+1) 617-353-2493
b
Merck Research Laboratories-Boston: 3-120, 33 Avenue Louis Pasteur, Boston
E-mail: david_sloman@merck.com
; Tel: (+1) 617-992-2063
Nat. Prod. Rep., 2013,30, 382-391
DOI:
10.1039/C3NP20122H
Received
04 Dec 2012,
First published online
21 Jan 2013
Polycyclic xanthone natural products are a family of polyketides which are characterized by highly oxygenated, angular hexacyclic frameworks. In the last decade, this novel class of molecules has attracted noticeable attention from the synthetic and biological communities due to emerging reports of their potential use as antitumour agents. The aim of this article is to highlight the most recent developments of this subset of the xanthone family by detailing the innate challenges of the construction of this class of natural products, new synthetic approaches, and pharmacological data.
A review, with 28 references, highlighting recent developments on polycyclic xanthone natural products, including synthetic approaches and pharmacological data.
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