Issue 12, 2013

Octupolar chimeric compounds built from quinoline caged acetate moieties: a novel approach for 2-photon uncaging of biomolecules

Abstract

The present study describes the synthesis and investigation of chimeric structures where 6-quinoline and 8-quinoline caging units are integrated in multipolar systems to yield “hybrid” molecular structures for two-photon uncaging. These systems were demonstrated to exhibit strikingly enhanced (up to more than 2 orders of magnitude larger for octupolar derivatives) two-photon absorption responses in the NIR region compared to common caging groups. Whereas the quadrupolar compound shows the lowest two-photon uncaging cross-section (δu), octupolar chimeric derivatives display one-order larger δu values than their dipolar analogues. This opens a promising route for the design of efficient octupolar type derivatives for two-photon uncaging of biomolecules.

Graphical abstract: Octupolar chimeric compounds built from quinoline caged acetate moieties: a novel approach for 2-photon uncaging of biomolecules

Supplementary files

Article information

Article type
Paper
Submitted
25 Jul 2013
Accepted
03 Sep 2013
First published
05 Sep 2013

New J. Chem., 2013,37, 3899-3913

Octupolar chimeric compounds built from quinoline caged acetate moieties: a novel approach for 2-photon uncaging of biomolecules

S. Picard, E. Genin, G. Clermont, V. Hugues, O. Mongin and M. Blanchard-Desce, New J. Chem., 2013, 37, 3899 DOI: 10.1039/C3NJ00833A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements