Jump to main content
Jump to site search

Issue 10, 2013
Previous Article Next Article

An intrinsically fluorescent glycoligand for direct imaging of ligand trafficking in artificial and living cell systems

Author affiliations

Abstract

Glycoligands, sugar-based molecules able to complex metal cations, constitute a new class of molecules with great potential for biological and biochemical applications. To analyze their behaviour in a biological environment, we have synthesized an intrinsically fluorescent glycoligand and analyzed its trafficking in both living (U937 human cancer cells) and artificial (giant unilamellar vesicles) cell systems. We have found that this ligand has moderate cytotoxicity accompanied by specific accumulation in both living and reconstituted membranes, which it can cross to reach inner compartments.

Graphical abstract: An intrinsically fluorescent glycoligand for direct imaging of ligand trafficking in artificial and living cell systems

Back to tab navigation

Publication details

The article was received on 10 Apr 2013, accepted on 08 Jul 2013 and first published on 08 Jul 2013


Article type: Paper
DOI: 10.1039/C3NJ00380A
Citation: New J. Chem., 2013,37, 3030-3034
  •   Request permissions

    An intrinsically fluorescent glycoligand for direct imaging of ligand trafficking in artificial and living cell systems

    L. Garcia, M. Lazzaretti, A. Diguet, F. Mussi, F. Bisceglie, J. Xie, G. Pelosi, A. Buschini, D. Baigl and C. Policar, New J. Chem., 2013, 37, 3030
    DOI: 10.1039/C3NJ00380A

Search articles by author

Spotlight

Advertisements