Novel sphingosine-containing analogues selectively inhibit sphingosine kinase (SK) isozymes, induce SK1 proteasomal degradation and reduce DNA synthesis in human pulmonary arterial smooth muscle cells†
Abstract
* Corresponding authors
a
Department of Chemistry and Biochemistry, Queens College, The City University of New York, Flushing, NY 11367-1597, USA
E-mail:
robert.bittman@qc.cuny.edu
Tel: +1 718-997-3279
b Cell Biology Group, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UK
H. Byun, S. Pyne, N. MacRitchie, N. J. Pyne and R. Bittman, Med. Chem. Commun., 2013, 4, 1394 DOI: 10.1039/C3MD00201B
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