Jump to main content
Jump to site search

Issue 9, 2013
Previous Article Next Article

Peptides: minimal drug surrogates to interrogate and interfere with protein function

Author affiliations

Abstract

The interactome in normal and disease cells is a key area for study and therapeutic targeting, yet few molecules have been developed that can interfere with proteinprotein interactions within cells. A variety of options are being examined to target proteinprotein interfaces in simple and in multi protein complexes. The work of Hamilton and colleagues has developed approaches to the synthesis of proteomimetics for this purpose and thus recognized novel scaffolds can be critical reagents to protein targets. In this short report, we have outlined two of our own molecular biology approaches to specific peptide isolation targeting protein interfaces for peptide design, with the goal being eventual therapeutic intervention.

Graphical abstract: Peptides: minimal drug surrogates to interrogate and interfere with protein function

Back to tab navigation

Publication details

The article was received on 20 May 2013, accepted on 10 Jul 2013 and first published on 19 Jul 2013


Article type: Review Article
DOI: 10.1039/C3MD00142C
Citation: Med. Chem. Commun., 2013,4, 1218-1221
  •   Request permissions

    Peptides: minimal drug surrogates to interrogate and interfere with protein function

    A. Cruz-Migoni, N. Fuentes-Fernandez and T. H. Rabbitts, Med. Chem. Commun., 2013, 4, 1218
    DOI: 10.1039/C3MD00142C

Search articles by author

Spotlight

Advertisements