The use of 111Ag as a tool for studying biological distribution of silver-based antimicrobials

Tolulope A. Aweda; Oluwatayo Ikotun; Tara Mastren; Carolyn L. Cannon; Brian Wright; Wiley J. Youngs; Cathy Cutler; James Guthrie; Suzanne E. Lapi

doi:10.1039/C3MD00082F

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The use of ¹¹¹Ag as a tool for studying biological distribution of silver-based antimicrobials†

Tolulope A. Aweda,^a Oluwatayo Ikotun,^a Tara Mastren,^a Carolyn L. Cannon,^b Brian Wright,^c Wiley J. Youngs,^c Cathy Cutler,^d James Guthrie^d and Suzanne E. Lapi*^a

Author affiliations

* Corresponding authors

^a Mallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, 510 S. Kingshighway Blvd, St. Louis, MO 63110, USA
E-mail: awedat@mir.wustl.edu, ikotuno@mir.wustl.edu, tmastren@wustl.edu, lapis@mir.wustl.edu
Fax: +1-314-362-9940
Tel: +1-314-362-0284

^b Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9063, USA
E-mail: carolyn.cannon@utsouthwestern.edu
Fax: +1-214-456-5406
Tel: +1-214-648-8709

^c Department of Chemistry, University of Akron, Akron, OH 44325-3601, USA
E-mail: bdw12@zips.uakron.edu, youngs@uakron.edu

^d University of Missouri, Research Reactor Center, 1513 Research Park Drive, Columbia, MO 65211, USA
E-mail: CutlerC@missouri.edu, GuthrieJM@missouri.edu
Fax: +1-573-882-5211
Tel: +1-573-882-6360

Abstract

Recently, there has been an emergence of significant interest in silver-based antimicrobials. Our goal was to develop a radioactive tracer for investigating the biological fate of such compounds. Purified ¹¹¹Ag was incorporated into the methylated caffeine analogue, IC1 to yield the silver carbene complex designated as [¹¹¹Ag]SCC1 and investigated in biodistribution studies.

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Article information

DOI: https://doi.org/10.1039/C3MD00082F
Article type: Concise Article
Submitted: 13 Mar 2013
Accepted: 01 May 2013
First published: 02 May 2013

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Med. Chem. Commun., 2013,4, 1015-1017

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The use of ¹¹¹Ag as a tool for studying biological distribution of silver-based antimicrobials

T. A. Aweda, O. Ikotun, T. Mastren, C. L. Cannon, B. Wright, W. J. Youngs, C. Cutler, J. Guthrie and S. E. Lapi, Med. Chem. Commun., 2013, 4, 1015 DOI: 10.1039/C3MD00082F

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