Design and synthesis of novel 18F-radiolabelled glucosamine derivatives for cancer imaging

Laurence Carroll; Timothy H. Witney; Eric O. Aboagye

doi:10.1039/C3MD00023K

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Design and synthesis of novel ¹⁸F-radiolabelled glucosamine derivatives for cancer imaging†

Laurence Carroll,*^a Timothy H. Witney^a and Eric O. Aboagye^a

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* Corresponding authors

^a Comprehensive Cancer Imaging Centre, Department of Surgery & Cancer, Hammersmith Campus, Imperial College, London, UK
E-mail: l.carroll@imperial.ac.uk
Tel: +44 (0)20 83833759

Abstract

The radiosynthesis of glucosamine and similar analogues would be of great interest due to their role in the biochemical synthesis of glycosylated proteins and lipids. This biochemistry can be exploited for visualisation of cancer cells via molecular imaging. This report details the synthesis of a number of ¹⁸F-labelled glucosamine derivatives and evaluation of their tumour uptake and normal tissue distribution in vivo in a mouse model of cancer by positron emission tomography (PET) imaging.

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Article information

DOI: https://doi.org/10.1039/C3MD00023K
Article type: Concise Article
Submitted: 17 Jan 2013
Accepted: 29 Jan 2013
First published: 05 Feb 2013

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Med. Chem. Commun., 2013,4, 653-656

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Design and synthesis of novel ¹⁸F-radiolabelled glucosamine derivatives for cancer imaging

L. Carroll, T. H. Witney and E. O. Aboagye, Med. Chem. Commun., 2013, 4, 653 DOI: 10.1039/C3MD00023K

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