Issue 7, 2013

Emerging trends in G-quadruplex biology – role in epigenetic and evolutionary events

Abstract

G-quadruplex biology gained interest based on evidence supporting its widespread role as elements that can control or modulate gene regulation. This followed initial prediction based on computational analysis that found prevalence of quadruplex motifs in promoters of many bacterial and other organisms. In parallel, further evidence was found indicating the function of quadruplex motifs in replication, recombination and also DNA repair. In this review, we summarize recent findings that provide a new perspective by introducing quadruplex motifs in roles that support involvement during epigenetic events, in determining evolutionary selection and as possible determinants of quantitative expression traits (eQTL) across populations.

Graphical abstract: Emerging trends in G-quadruplex biology – role in epigenetic and evolutionary events

Article information

Article type
Review Article
Submitted
31 Oct 2012
Accepted
24 Jan 2013
First published
24 Jan 2013

Mol. BioSyst., 2013,9, 1568-1575

Emerging trends in G-quadruplex biology – role in epigenetic and evolutionary events

A. Baral, P. Kumar, R. Pathak and S. Chowdhury, Mol. BioSyst., 2013, 9, 1568 DOI: 10.1039/C3MB25492E

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