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Issue 4, 2013
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Metabolomic changes in gastrointestinal tissues after whole body radiation in a murine model

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Abstract

Exposure to ionizing radiation (IR) elicits a set of complex biological responses involving gene expression and protein turnover that ultimately manifest as dysregulation of metabolic processes representing the cellular phenotype. Although radiation biomarkers have been reported in urine and serum, they are not informative about IR mediated tissue or organ specific injury. In the present study we report IR induced metabolic changes in gastrointestinal (GI) tissue of CD2F1 mice using ultra-performance liquid chromatography (UPLC) coupled with electrospray time-of-flight mass spectrometry. Post-radiation GI injury is a critical determinant of survival after exposure to IR. Our results show a distinct dose and time dependent response to GI tissue injury.

Graphical abstract: Metabolomic changes in gastrointestinal tissues after whole body radiation in a murine model

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Publication details

The article was received on 16 Oct 2012, accepted on 18 Jan 2013 and first published on 21 Jan 2013


Article type: Paper
DOI: 10.1039/C3MB25454B
Citation: Mol. BioSyst., 2013,9, 723-731
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    Metabolomic changes in gastrointestinal tissues after whole body radiation in a murine model

    S. P. Ghosh, R. Singh, K. Chakraborty, S. Kulkarni, A. Uppal, Y. Luo, P. Kaur, R. Pathak, K. S. Kumar, M. Hauer-Jensen and A. K. Cheema, Mol. BioSyst., 2013, 9, 723
    DOI: 10.1039/C3MB25454B

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