Jump to main content
Jump to site search

Issue 24, 2013
Previous Article Next Article

Actively transporting virus like analytes with optofluidics for rapid and ultrasensitive biodetection

Author affiliations

Abstract

Effective analyte delivery is essential to achieve rapid and sensitive biodetection systems. In this article, we present an actively controlled fluidic system integrated with a suspended plasmonic nanohole sensor to achieve superior analyte delivery efficiency and ultrafast sensor response, as compared to conventional fluidic systems. 70 nm sized virus like analyte solution is used to experimentally demonstrate the system performance improvements. Sensor response time is reduced by one order of magnitude as compared to the conventional methods. A seven orders of magnitude dynamic concentration range from 103 to 109 particles mL−1 is quantified, corresponding to a concentration window relevant to clinical diagnosis and drug screening. Our non-destructive detection system, by enabling efficient analyte delivery, fast sensing response and minimal sample volume, opens up opportunities for sensitive, rapid and real-time virus detection in infectious disease control and point-of-care applications.

Graphical abstract: Actively transporting virus like analytes with optofluidics for rapid and ultrasensitive biodetection

Back to tab navigation

Supplementary files

Publication details

The article was received on 09 Jul 2013, accepted on 23 Sep 2013 and first published on 23 Sep 2013


Article type: Paper
DOI: 10.1039/C3LC50814E
Citation: Lab Chip, 2013,13, 4841-4847
  •   Request permissions

    Actively transporting virus like analytes with optofluidics for rapid and ultrasensitive biodetection

    M. Huang, B. C. Galarreta, A. E. Cetin and H. Altug, Lab Chip, 2013, 13, 4841
    DOI: 10.1039/C3LC50814E

Search articles by author

Spotlight

Advertisements