Issue 7, 2013
From the journal:

Green Chemistry

A general and practical oxidation of alcohols to primary amides under metal-free conditions†‡

Xiao-Feng Wu,*ab   Muhammad Sharif,bc   Jian-Bo Feng,a   Helfried Neumann,b   Anahit Pews-Davtyan,b   Peter Langerbd  and  Matthias Beller*b  

* Corresponding authors

a Department of Chemistry, Zhejiang Sci-Tech University, Xiasha Campus, Hangzhou, Zhejiang Province, People's Republic of China
E-mail: xiao-feng.wu@catalysis.de
Tel: (+49)381-1281-343

b Leibniz-Institut für Katalyse an der Universität Rostock e.V. Albert-Einstein-Str. 29a, 18059 Rostock, Germany
E-mail: matthias.beller@catalysis.de

c Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad, Pakistan

d Institut für Chemie, Universität Rostock, Albert-Einstein-Str. 3a, 18059 Rostock, Germany

Abstract

A general procedure for oxidation of both benzyl alcohols and alkyl alcohols to primary amides under catalyst free conditions has been developed. 34 examples of primary amides were produced from their corresponding alcohols in moderate to excellent yields. This is a practical procedure for primary amides synthesis; water and tert-butanol are the only by-products. A commercial drug, Piracetam, was prepared in one step with 73% yield as well.

Graphical abstract: A general and practical oxidation of alcohols to primary amides under metal-free conditions

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C3GC40668G
Article type
Paper
Submitted
09 Apr 2013
Accepted
30 Apr 2013
First published
01 May 2013

Green Chem., 2013,15, 1956-1961

Permissions

Request permissions

A general and practical oxidation of alcohols to primary amides under metal-free conditions

X. Wu, M. Sharif, J. Feng, H. Neumann, A. Pews-Davtyan, P. Langer and M. Beller, Green Chem., 2013, 15, 1956 DOI: 10.1039/C3GC40668G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements