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Issue 8, 2013
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Beneficial effect of tagatose consumption on postprandial hyperglycemia in Koreans: a double-blind crossover designed study

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Abstract

The present study determined the effect of tagatose supplementation on postprandial hyperglycemia in normal (n = 54) and hyperglycemic subjects [n = 40, impaired fasting glucose (IFG) and newly diagnosed type 2 diabetes]. In a double-blind crossover designed study, study subjects were randomly assigned to consume a sucralose–erythritol drink (the placebo) or a tagatose-containing drink (the test) with a seven-day interval. Finally, 85 subjects completed the study (normal, n = 52; hyperglycemic, n = 33). Blood samples were collected at 0, 30, 60 and 120 min after ingestion and analyzed for fasting and postprandial levels of glucose, insulin and C-peptide. Basic anthropometric parameters and lipid files were also measured. Hyperglycemic subjects were basically older and heavier, and showed higher levels of triglyceride, total- and LDL-cholesterols and apolipoprotein AI and B compared with normal subjects. After consuming the tagatose (5 g)-containing drink, hyperglycemic subjects had a significant reduction in serum levels of glucose at 120 min (p = 0.019) and glucose area under the curve (AUC) (p = 0.017), however these were not observed in normal subjects. When ages were matched between the two groups, the glucose response patterns were shown to be similar. Additionally, normal subjects who received a high-dose of tagatose-containing drinks (10 g) showed significantly lower levels of insulin at 30 min (p = 0.004) and 60 min (p = 0.011), insulin AUC (p = 0.009), and C-peptide at 30 min (p = 0.004), 60 min (p = 0.011) and C-peptide AUC (p = 0.023). In conclusion, a single dietary supplement in the form of a tagatose-containing drink may be beneficial for controlling postprandial glycemic response in Koreans.

Graphical abstract: Beneficial effect of tagatose consumption on postprandial hyperglycemia in Koreans: a double-blind crossover designed study

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Publication details

The article was received on 04 Jan 2013, accepted on 19 May 2013 and first published on 20 May 2013


Article type: Paper
DOI: 10.1039/C3FO00006K
Citation: Food Funct., 2013,4, 1223-1228
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    Beneficial effect of tagatose consumption on postprandial hyperglycemia in Koreans: a double-blind crossover designed study

    J. H. Kwak, M. S. Kim, J. H. Lee, Y. J. Yang, K. H. Lee, O. Y. Kim and J. H. Lee, Food Funct., 2013, 4, 1223
    DOI: 10.1039/C3FO00006K

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