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Volume 161, 2013
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Elastic properties of polyunsaturated phosphatidylethanolamines influence rhodopsin function

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Abstract

Membranes with a high content of polyunsaturated phosphatidylethanolamines (PE) facilitate formation of metarhodopsin-II (MII), the photointermediate of bovine rhodopsin that activates the G protein transducin. We determined whether MII-formation is quantitatively linked to the elastic properties of PEs. Curvature elasticity of monolayers of the polyunsaturated lipids 18 : 0–22 : 6n − 3PE, 18 : 0–22 : 5n − 6PE and the model lipid 18 : 1n − 9–18 : 1n − 9PE were investigated in the inverse hexagonal phase. All three lipids form lipid monolayers with rather low spontaneous radii of curvature of 26–28 Å. In membranes, all three PEs generate high negative curvature elastic stress that shifts the equilibrium of MI/MII photointermediates of rhodopsin towards MII formation.

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Publication details

The article was received on 02 May 2012, accepted on 28 Jun 2012 and first published on 29 Jun 2012


Article type: Paper
DOI: 10.1039/C2FD20095C
Citation: Faraday Discuss., 2013,161, 383-395
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    Elastic properties of polyunsaturated phosphatidylethanolamines influence rhodopsin function

    W. E. Teague, O. Soubias, H. Petrache, N. Fuller, K. G. Hines, R. P. Rand and K. Gawrisch, Faraday Discuss., 2013, 161, 383
    DOI: 10.1039/C2FD20095C

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