FRET-based ratiometric fluorescent probes for selective Fe3+ sensing and their applications in mitochondria

Wen-dan Chen; Wei-tao Gong; Zhi-qiang Ye; Yuan Lin; Gui-ling Ning

doi:10.1039/C3DT50832C

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FRET-based ratiometric fluorescent probes for selective Fe³⁺ sensing and their applications in mitochondria†

Wen-dan Chen,^a Wei-tao Gong,*^a Zhi-qiang Ye,^b Yuan Lin^a and Gui-ling Ning*^a

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* Corresponding authors

^a State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Dalian, China
E-mail: wtgong@dlut.edu.cn, ninggl@dlut.edu.cn
Fax: +86 411-8498-6065
Tel: +86 411-8498-6067

^b State Key Laboratory of Fine Chemicals, School of Chemistry, Dalian University of Technology, Dalian, China
E-mail: zhiqiangye2001@yahoo.com.cn
Fax: +86 411-8498-6041
Tel: +86 411-8498-6041

Abstract

Efficient ratiometric fluorescent Fe³⁺ probes were designed and synthesized by linking a conjugated naphthalene chromophore to a rhodamine platform and a lipophilic triphenylphosphonium (TPP) cation. The probes could sensitively and selectively detect mitochondrial Fe³⁺ in living cells.

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Article information

DOI: https://doi.org/10.1039/C3DT50832C
Article type: Communication
Submitted: 28 Mar 2013
Accepted: 07 May 2013
First published: 09 May 2013

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Dalton Trans., 2013,42, 10093-10096

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FRET-based ratiometric fluorescent probes for selective Fe³⁺ sensing and their applications in mitochondria

W. Chen, W. Gong, Z. Ye, Y. Lin and G. Ning, Dalton Trans., 2013, 42, 10093 DOI: 10.1039/C3DT50832C

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Dalton Transactions