Issue 10, 2014

Enhanced cellular uptake of amphiphilic gold nanoparticles with ester functionality

Abstract

Gold nanoparticles (AuNPs) coated with ester-headed or ether-headed PEG ligands were synthesized. Ester-headed AuNPs, but not ether-headed, were transferred from the organic phase (CH2Cl2) to the alkali aqueous phase, indicating that the hydrolysis of the ester moiety triggered the phase transfer of the AuNPs. We found that AuNPs with ester-headed ligands (ester-AuNPs) were internalized into HeLa cells at a greater level than were ether-headed AuNPs.

Graphical abstract: Enhanced cellular uptake of amphiphilic gold nanoparticles with ester functionality

Supplementary files

Article information

Article type
Communication
Submitted
08 Nov 2013
Accepted
26 Nov 2013
First published
26 Nov 2013

Chem. Commun., 2014,50, 1265-1267

Author version available

Enhanced cellular uptake of amphiphilic gold nanoparticles with ester functionality

K. Kobayashi, K. Niikura, C. Takeuchi, S. Sekiguchi, T. Ninomiya, K. Hagiwara, H. Mitomo, Y. Ito, Y. Osada and K. Ijiro, Chem. Commun., 2014, 50, 1265 DOI: 10.1039/C3CC48532C

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