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Issue 10, 2014
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Enhanced cellular uptake of amphiphilic gold nanoparticles with ester functionality

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Abstract

Gold nanoparticles (AuNPs) coated with ester-headed or ether-headed PEG ligands were synthesized. Ester-headed AuNPs, but not ether-headed, were transferred from the organic phase (CH2Cl2) to the alkali aqueous phase, indicating that the hydrolysis of the ester moiety triggered the phase transfer of the AuNPs. We found that AuNPs with ester-headed ligands (ester-AuNPs) were internalized into HeLa cells at a greater level than were ether-headed AuNPs.

Graphical abstract: Enhanced cellular uptake of amphiphilic gold nanoparticles with ester functionality

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Publication details

The article was received on 08 Nov 2013, accepted on 26 Nov 2013 and first published on 26 Nov 2013


Article type: Communication
DOI: 10.1039/C3CC48532C
Citation: Chem. Commun., 2014,50, 1265-1267
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    Enhanced cellular uptake of amphiphilic gold nanoparticles with ester functionality

    K. Kobayashi, K. Niikura, C. Takeuchi, S. Sekiguchi, T. Ninomiya, K. Hagiwara, H. Mitomo, Y. Ito, Y. Osada and K. Ijiro, Chem. Commun., 2014, 50, 1265
    DOI: 10.1039/C3CC48532C

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