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Issue 40, 2014
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Mechanosynthesis of pharmaceutically relevant sulfonyl-(thio)ureas

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Abstract

We demonstrate the first application of mechanochemistry to conduct the synthesis of sulfonyl-(thio)ureas, including known anti-diabetic drugs tolbutamide, chlorpropamide and glibenclamide, in good to excellent isolated yields by either stoichiometric base-assisted or copper-catalysed coupling of sulfonamides and iso(thio)cyanates.

Graphical abstract: Mechanosynthesis of pharmaceutically relevant sulfonyl-(thio)ureas

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Publication details

The article was received on 14 Oct 2013, accepted on 29 Oct 2013 and first published on 31 Oct 2013


Article type: Communication
DOI: 10.1039/C3CC47905F
Citation: Chem. Commun., 2014,50, 5248-5250
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    Mechanosynthesis of pharmaceutically relevant sulfonyl-(thio)ureas

    D. Tan, V. Štrukil, C. Mottillo and T. Friščić, Chem. Commun., 2014, 50, 5248
    DOI: 10.1039/C3CC47905F

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