Issue 26, 2014
From the journal:

Chemical Communications

Modulation of raft domains in a lipid bilayer by boundary-active curcumin†

Manami Tsukamoto,a   Kenichi Kuroda,*b   Ayyalusamy Ramamoorthy*c  and  Kazuma Yasuhara*a  

* Corresponding authors

a Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 6300192, Japan
E-mail: yasuhara@ms.naist.jp
Fax: +81-743-72-6099
Tel: +81-743-72-6093

b Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1011 N. University Ave., Ann Arbor, MI 48109, USA
E-mail: kkuroda@umich.edu
Fax: +1-734-647-2110
Tel: +1-734-936-1440

c Biophysics and Department of Chemistry, University of Michigan, 930 N. University Ave., Ann Arbor, MI 48109, USA
E-mail: ramamoor@umich.edu
Fax: +1-734-764-3323
Tel: +1-734-647-6572

Abstract

The function and mode of action of curcumin in modulating the formation of lipid raft domains were investigated by microscopic observation using model membranes. Curcumin induces fusion of lipid raft domains at extremely low concentrations through the alteration of the boundary between the ordered and disordered phases.

Graphical abstract: Modulation of raft domains in a lipid bilayer by boundary-active curcumin

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C3CC47738J
Article type
Communication
Submitted
08 Oct 2013
Accepted
16 Dec 2013
First published
16 Dec 2013

Chem. Commun., 2014,50, 3427-3430

Permissions

Request permissions

Modulation of raft domains in a lipid bilayer by boundary-active curcumin

M. Tsukamoto, K. Kuroda, A. Ramamoorthy and K. Yasuhara, Chem. Commun., 2014, 50, 3427 DOI: 10.1039/C3CC47738J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements