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Issue 40, 2014
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Targeting cancer cells with folic acid–iminoboronate fluorescent conjugates

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Abstract

Herein we present the synthesis of fluorescent 2-acetylbenzeneboronic acids that undergo B–N promoted conjugation with lysozyme and N-(2-aminoethyl) folic acid (EDA-FA), generating conjugates that are selectively recognized and internalized by cancer cells that over-express folic acid receptors.

Graphical abstract: Targeting cancer cells with folic acid–iminoboronate fluorescent conjugates

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Publication details

The article was received on 01 Oct 2013, accepted on 04 Nov 2013 and first published on 05 Nov 2013


Article type: Communication
DOI: 10.1039/C3CC47534D
Citation: Chem. Commun., 2014,50, 5261-5263
  • Open access: Creative Commons BY license
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    Targeting cancer cells with folic acid–iminoboronate fluorescent conjugates

    P. M. S. D. Cal, R. F. M. Frade, V. Chudasama, C. Cordeiro, S. Caddick and P. M. P. Gois, Chem. Commun., 2014, 50, 5261
    DOI: 10.1039/C3CC47534D

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