Issue 40, 2014
From the journal:

Chemical Communications

γ-AApeptide-based small-molecule ligands that inhibit Aβ aggregation†

Haifan Wu,a   Yaqiong Li,a   Ge Bai,a   Youhong Niu,a   Qiao Qiao,a   Jeremiah D. Tipton,b   Chuanhai Cao*c  and  Jianfeng Cai*a  

* Corresponding authors

a Department of Chemistry, University of South Florida, 4202 E. Fowler Ave, Tampa, FL 33620, USA
E-mail: jianfengcai@usf.edu
Fax: +1 831-874-3203
Tel: +1 813-974-9506

b Proteomics and Mass Spectrometry, USF CDDI, 3720 Spectrum Blvd., Tampa, FL 33612, USA

c College of Pharmacy, University of South Florida, 4202 E. Fowler Ave, Tampa, FL 33620, USA
E-mail: ccao@health.usf.edu

Abstract

We report the design, synthesis, characterization and evaluation of a novel class of γ-AApeptide one-bead-one-compound (OBOC) library, from which a small γ-AApeptide was identified to effectively prevent and disassemble Aβ aggregation.

Graphical abstract: γ-AApeptide-based small-molecule ligands that inhibit Aβ aggregation

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Article information

DOI
https://doi.org/10.1039/C3CC46685J
Article type
Communication
Submitted
01 Sep 2013
Accepted
10 Oct 2013
First published
10 Oct 2013

Chem. Commun., 2014,50, 5206-5208

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γ-AApeptide-based small-molecule ligands that inhibit Aβ aggregation

H. Wu, Y. Li, G. Bai, Y. Niu, Q. Qiao, J. D. Tipton, C. Cao and J. Cai, Chem. Commun., 2014, 50, 5206 DOI: 10.1039/C3CC46685J

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