Issue 85, 2013
From the journal:

Chemical Communications

Trichloromethyl ketones: asymmetric transfer hydrogenation and subsequent Jocic-type reactions with amines†

Michael S. Perryman,a   Matthew E. Harris,a   Jade L. Foster,a   Anushka Joshi,a   Guy J. Clarksona  and  David J. Fox*a  

* Corresponding authors

a Department of Chemistry, University of Warwick, Gibbet Hill, Coventry, CV4 7AL, UK
E-mail: d.j.fox@warwick.ac.uk
Fax: +44 (0)2476524112
Tel: +44 (0)2476524331

Abstract

Amino-amides are important pharmaceutical building-blocks. The enantioselective reduction of trichloromethyl ketones using ruthenium transfer hydrogenation catalysts is reported. The products react in a range of Jocic-type reactions to give enantiomerically enriched amino-amides.

Graphical abstract: Trichloromethyl ketones: asymmetric transfer hydrogenation and subsequent Jocic-type reactions with amines

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Article information

DOI
https://doi.org/10.1039/C3CC46070C
Article type
Communication
Submitted
08 Aug 2013
Accepted
13 Sep 2013
First published
16 Sep 2013

Chem. Commun., 2013,49, 10022-10024

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Trichloromethyl ketones: asymmetric transfer hydrogenation and subsequent Jocic-type reactions with amines

M. S. Perryman, M. E. Harris, J. L. Foster, A. Joshi, G. J. Clarkson and D. J. Fox, Chem. Commun., 2013, 49, 10022 DOI: 10.1039/C3CC46070C

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